Spyware and adware are notorious for putting entries in the registry.  The Junk Key Editor has a list of such entries.  It is very likely that none are in your registry.  If this is the case, at the top of the listbox it will say "0 Junk Keys Found in the Registry".  If it doesn't say 0, then some of these entries are in your registry.  The items with a checkbox are the ones found in your registry.

Use the Uncheck All and Check All buttons to uncheck or check all of the items.  Even though the item may not have a checkbox, it still is either checked or unchecked (even though it will not be visible).  This status is saved for future reference.  It is recommended to keep them all checked (this can be done by clicking on the Check All button), especially if you are running the Junk Key Editor in automated scans.  That way your registry will automatically be checked and cleaned for these entries.

The Show Key button opens RegEdit and shows you where the key is in the registry.

Click on the Clean Checked Items Above button to clean the checked items.

 

The "Delete checked Junk Keys as part of Automated Scans" checkbox lets you include the Junk Key Editor in the automated scans.